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1

Prevalence and Risk Factors for Mycobacterium bovis Infection in African Lions ( Panthera leo ) in the Kruger National Park

Sylvester, Tashnica Taime, Martin, Laura Elizabeth Rosen, Buss, Peter, Loxton, Andre Gareth, Hausler, Guy Anton, Rossouw, Leana, van Helden, Paul, Parsons, Sven David Charles, Olea-Popelka, Francisco,

Journal:

Journal of Wildlife Diseases

Year:

2017

Language:

english

File:

PDF, 143 KB

english, 2017

2

Potential of novelMycobacterium tuberculosisinfection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Novel N Chegou, Gillian F Black, Andre G Loxton, Kim Stanley, Paulin N Essone, Michel R Klein, Shreemanta K Parida, Stefan HE Kaufmann, T Mark Doherty, Annemieke H Friggen, Kees L Franken, Tom H Otten

Journal:

BMC Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 327 KB

english, 2012

3

Increased Frequency of Myeloid-derived Suppressor Cells during Active Tuberculosis and after Recent Mycobacterium tuberculosis Infection Suppresses T-Cell Function

du Plessis, Nelita, Loebenberg, Laurianne, Kriel, Magdalena, von Groote-Bidlingmaier, Florian, Ribechini, Eliana, Loxton, Andre G., van Helden, Paul D., Lutz, Manfred B., Walzl, Gerhard

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

4

Mycobacterium bovisBCG infection severely delaysTrichuris murisexpulsion and co-infection suppresses immune responsiveness to both pathogens

Nel, Hendrik J, du Plessis, Nelita, Kleynhans, Leanie, Loxton, André G, van Helden, Paul D, Walzl, Gerhard

Journal:

BMC Microbiology

Year:

2014

Language:

english

File:

PDF, 429 KB

english, 2014

5

Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

Mihret, Adane, Loxton, Andre G, Bekele, Yonas, Kaufmann, Stefan HE, Kidd, Martin, Haks, Mariëlle C, Ottenhoff, Tom HM, Aseffa, Abraham, Howe, Rawleigh, Walzl, Gerhard

Journal:

BMC Infectious Diseases

Year:

2014

Language:

english

File:

PDF, 327 KB

english, 2014

6

Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets

Baumann, Ralf, Kaempfer, Susanne, Chegou, Novel N., Oehlmann, Wulf, Loxton, André G., Kaufmann, Stefan H.E., van Helden, Paul D., Black, Gillian F., Singh, Mahavir, Walzl, Gerhard

Journal:

Journal of Infection

Year:

2014

Language:

english

File:

PDF, 734 KB

english, 2014

7

Sequence Analysis of Near Full-Length HIV Type 1 Subtype D Primary Strains Isolated in Cape Town, South Africa, from 1984 to 1986

Loxton, André G., Treurnicht, Florette, Laten, Annette, Rensburg, Estrelita Janse Van, Engelbrecht, Susan

Journal:

AIDS Research and Human Retroviruses

Year:

2005

Language:

english

File:

PDF, 77 KB

english, 2005

8

Complete Genome Sequencing of a Non-syncytium-Inducing HIV Type 1 Subtype D Strain from Cape Town, South Africa

Jacobs, Graeme B., Loxton, André G., Laten, Annette, Engelbrecht, Susan

Journal:

AIDS Research and Human Retroviruses

Year:

2007

Language:

english

File:

PDF, 369 KB

english, 2007

9

Transcriptomics: the key to biomarker discovery during tuberculosis?

van Rensburg, Ilana C, Loxton, André G

Journal:

Biomarkers in Medicine

Year:

2015

Language:

english

File:

PDF, 1.75 MB

english, 2015

10

Bifunctional T-Cell-Derived Cytokines for the Diagnosis of Tuberculosis and Treatment Monitoring

Essone, Paulin N., Kalsdorf, Barbara, Chegou, Novel N., Loxton, André G., Kriel, Magdalena, Preyer, Rosemarie, Ernst, Martin, Walzl, Gerhard, Lange, Christoph

Journal:

Year:

2014

Language:

english

File:

PDF, 652 KB

english, 2014

11

Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis

Mihret, Adane, Bekele, Yonas, Loxton, Andre G., Aseffa, Abraham, Howe, Rawleigh, Walzl, Gerhard

Journal:

Journal of Tropical Medicine

Year:

2012

Language:

english

File:

PDF, 435 KB

english, 2012

12

Diversity of Mycobacterium tuberculosis Isolates from New Pulmonary Tuberculosis Cases in Addis Ababa, Ethiopia

Mihret, Adane, Bekele, Yonas, Loxton, Andre G., Jordan, Annemie M., Yamuah, Lawrence, Aseffa, Abraham, Howe, Rawleigh, Walzl, Gerhard

Journal:

Tuberculosis Research and Treatment

Year:

2012

Language:

english

File:

PDF, 284 KB

english, 2012

13

Differential Expression of Host Biomarkers in Saliva and Serum Samples from Individuals with Suspected Pulmonary Tuberculosis

Phalane, Khutso G., Kriel, Magdalena, Loxton, Andre G., Menezes, Angela, Stanley, Kim, van der Spuy, Gian D., Walzl, Gerhard, Chegou, Novel N.

Journal:

Mediators of Inflammation

Year:

2013

Language:

english

File:

PDF, 621 KB

english, 2013

14

Frequency of Mycobacterium tuberculosis-specific CD8+ T-cells in the course of anti-tuberculosis treatment

Axelsson-Robertson, Rebecca, Rao, Martin, Loxton, Andre G., Walzl, Gerhard, Bates, Matthew, Zumla, Alimuddin, Maeurer, Markus

Journal:

International Journal of Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

15

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers

Esterhuyse, Maria M., Weiner, January, Caron, Etienne, Loxton, Andre G., Iannaccone, Marco, Wagman, Chandre, Saikali, Philippe, Stanley, Kim, Wolski, Witold E., Mollenkopf, Hans-Joachim, Schick, Matth

Journal:

Year:

2015

Language:

english

File:

PDF, 669 KB

english, 2015

16

QuantiFERON-TB performance enhanced by novel Mycobacterium tuberculosis -specific antigens: TABLE 1

Losi, Monica, Knights, Ashley J., Mariani, Francesca, Altieri, Alfonso M., Paone, Gregorino, Loxton, Andre G., Chegou, Novel N., Kenneth, John, Alma, Mario G., Colizzi, Vittorio, Walzl, Gerhard, Salti

Journal:

European Respiratory Journal

Year:

2015

Language:

english

File:

PDF, 269 KB

english, 2015

17

B cells as multi-functional players during Mycobacterium tuberculosis infection and disease

du Plessis, Willem J., Walzl, Gerhard, Loxton, André G.

Journal:

Year:

2015

Language:

english

File:

PDF, 348 KB

english, 2015

18

Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment

Jacobs, Ruschca, Tshehla, Enock, Malherbe, Stephanus, Kriel, Magdalena, Loxton, Andre G., Stanley, Kim, van der Spuy, Gian, Walzl, Gerhard, Chegou, Novel N.

Journal:

Year:

2016

Language:

english

File:

PDF, 453 KB

english, 2016

19

Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

Awoniyi, Dolapo O., Teuchert, Andrea, Sutherland, Jayne S., Mayanja-Kizza, Harriet, Howe, Rawleigh, Mihret, Adane, Loxton, Andre G., Sheehama, Jacob, Kassa, Desta, Crampin, Amelia C., Dockrell, Hazel

Journal:

Journal of Infection

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

20

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

Malherbe, Stephanus T, Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G, Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y, Warwick, James, Via, Laura E, Song, Taeksun, Lee, Myungsun,

Journal:

Nature Medicine

Year:

2016

Language:

english

File:

PDF, 1.65 MB

english, 2016

21

Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients

Garcia, Benjamin J., Loxton, Andre G., Dolganov, Gregory M., Van, Tran T., Davis, J. Lucian, de Jong, Bouke C., Voskuil, Martin I., Leach, Sonia M., Schoolnik, Gary K., Walzl, Gerhard, Strong, Michael

Journal:

Year:

2016

Language:

english

File:

PDF, 724 KB

english, 2016

22

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

Chegou, Novel N, Sutherland, Jayne S, Malherbe, Stephanus, Crampin, Amelia C, Corstjens, Paul L A M, Geluk, Annemieke, Mayanja-Kizza, Harriet, Loxton, Andre G, van der Spuy, Gian, Stanley, Kim, Kotzé,

Journal:

Year:

2016

Language:

english

File:

PDF, 1.08 MB

english, 2016

23

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa

Loxton, André G., Knaul, Julia K., Grode, Leander, Gutschmidt, Andrea, Meller, Christiane, Eisele, Bernd, Johnstone, Hilary, van der Spuy, Gian, Maertzdorf, Jeroen, Kaufmann, Stefan H. E., Hesseling,

Journal:

Clinical and Vaccine Immunology

Year:

2017

Language:

english

File:

PDF, 1.62 MB

english, 2017

24

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

Malherbe, Stephanus T, Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G, Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y, Warwick, James, Via, Laura E, Song, Taeksun, Lee, Myungsun,

Journal:

Nature Medicine

Year:

2017

Language:

english

File:

PDF, 56 KB

english, 2017

25

B-cells with a FasL expressing regulatory phenotype are induced following successful anti-tuberculosis treatment

van Rensburg, Ilana C., Kleynhans, Léanie, Keyser, Alana, Walzl, Gerhard, Loxton, Andre G.

Journal:

Immunity, Inflammation and Disease

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

26

B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis

Bénard, Alan, Sakwa, Imme, Schierloh, Pablo, Colom, André, Mercier, Ingrid, Tailleux, Ludovic, Jouneau, Luc, Boudinot, Pierre, Al-Saati, Talal, Lang, Roland, Rehwinkel, Jan, Loxton, Andre G, Kaufmann,

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2017

Language:

english

File:

PDF, 1.85 MB

english, 2017

27

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

Malherbe, Stephanus T, Shenai, Shubhada, Ronacher, Katharina, Loxton, Andre G, Dolganov, Gregory, Kriel, Magdalena, Van, Tran, Chen, Ray Y, Warwick, James, Via, Laura E, Song, Taeksun, Lee, Myungsun,

Journal:

Nature Medicine

Year:

2017

Language:

english

File:

PDF, 55 KB

english, 2017

28

Killer (FASL regulatory) B cells are present during latent TB and are induced by BCG stimulation in participants with and without latent tuberculosis

van Rensburg, Ilana C., Loxton, Andre G.

Journal:

Year:

2018

Language:

english

File:

PDF, 333 KB

english, 2018

29

COMBINED SPECIFIC IGG – AND IGA-BASED DIAGNOSIS OF TUBERCULOSIS IN AFRICAN PRIMARY HEALTHCARE CLINIC ATTENDEES WITH SIGNS AND SYMPTOMS SUGGESTIVE OF TUBERCULOSIS

Awoniyi, Dolapo, Baumann, Ralf, Chegou, Novel, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Walzl, Gerhard

Journal:

BMJ Global Health

Year:

2017

Language:

english

File:

PDF, 46 KB

english, 2017

30

A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+ T-Cell Immune Response in South African Patients with Active Tuberculosis

Axelsson-Robertson, Rebecca, Loxton, André G., Walzl, Gerhard, Ehlers, Marthie M., Kock, Marleen M., Zumla, Alimuddin, Maeurer, Markus, Scriba, Thomas Jens

Journal:

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

31

Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa

Sutherland, Jayne S., Lalor, Maeve K., Black, Gillian F., Ambrose, Lyn R., Loxton, Andre G., Chegou, Novel N., Kassa, Desta, Mihret, Adane, Howe, Rawleigh, Mayanja-Kizza, Harriet, Gomez, Marie P., Don

Journal:

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

32

Host Cytokine Responses Induced after Overnight Stimulation with Novel M. tuberculosis Infection Phase-Dependent Antigens Show Promise as Diagnostic Candidates for TB Disease

Essone, Paulin N., Chegou, Novel N., Loxton, Andre G., Stanley, Kim, Kriel, Magdalena, van der Spuy, Gian, Franken, Kees L., Ottenhoff, Tom H., Walzl, Gerhard, Dieli, Francesco

Journal:

Year:

2014

Language:

english

File:

PDF, 781 KB

english, 2014

33

A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens

Baumann, Ralf, Kaempfer, Susanne, Chegou, Novel N., Oehlmann, Wulf, Spallek, Ralf, Loxton, André G., van Helden, Paul D., Black, Gillian F., Singh, Mahavir, Walzl, Gerhard

Journal:

Mediators of Inflammation

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

34

The level of the endoplasmic reticulum stress chaperone protein, binding immunoglobulin protein (BiP), decreases following successful tuberculosis treatment

Motaung, Bongani, Walzl, Gerhard, Loxton, Andre G.

Journal:

International Journal of Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 552 KB

english, 2019

35

Isolation of B-cells using Miltenyi MACS bead isolation kits

Moore, Dannielle K., Motaung, Bongani, du Plessis, Nelita, Shabangu, Ayanda N., Loxton, André G., Chalmers, Jeffrey

Journal:

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

36

Effect of binding immunoglobulin protein on induction of regulatory B cells with killer phenotype during inflammation and disease

Motaung, Bongani, Loxton, Andre G

Journal:

Future Science OA

Year:

2019

Language:

english

File:

PDF, 1.62 MB

english, 2019

37

Bcells and their regulatory functions during Tuberculosis: Latency and active disease

Loxton, Andre G.

Journal:

Molecular Immunology

Year:

2019

Language:

english

File:

PDF, 699 KB

english, 2019

38

Performance and immune characteristics of bronchoalveolar lavage by research bronchoscopy in pulmonary tuberculosis and other lung diseases in the Western Cape, South Africa

Young, Carly, Ahlers, Petri, Hiemstra, Andriette M., Loxton, Andre G., Gutschmidt, Andrea, Malherbe, Stephanus T., Walzl, Gerhard, Du Plessis, Nelita

Journal:

Translational Medicine Communications

Year:

2019

Language:

english

File:

PDF, 2.15 MB

english, 2019

39

Performance and immune characteristics of bronchoalveolar lavage by research bronchoscopy in pulmonary tuberculosis and other lung diseases in the Western Cape, South Africa

Young, Carly, Ahlers, Petri, Hiemstra, Andriette M., Loxton, Andre G., Gutschmidt, Andrea, Malherbe, Stephanus T., Walzl, Gerhard, Du Plessis, Nelita

Journal:

Translational Medicine Communications

Year:

2019

File:

PDF, 2.15 MB

2019

40

Regulatory B lymphocytes: development and modulation of the host immune response during disease

Moore, Dannielle K, Loxton, Andre G

Journal:

Year:

2019

Language:

english

File:

PDF, 2.15 MB

english, 2019

41

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

Ronacher, Katharina, Chegou, Novel N., Kleynhans, Léanie, Djoba Siawaya, Joel F., du Plessis, Nelita, Loxton, André G., Maasdorp, Elizna, Tromp, Gerard, Kidd, Martin, Stanley, Kim, Kriel, Magdalena, M

Journal:

Year:

2019

Language:

english

File:

PDF, 1.39 MB

english, 2019

42

Detection of a combination of serum IgG and IgA antibodies against selected mycobacterial targets provides promising diagnostic signatures for active TB

Awoniyi, Dolapo O., Baumann, Ralf, Chegou, Novel N., Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre G., Kaempfer, Susanne, Singh, Mahavir, Walzl, Gerhard

Journal:

Year:

2017

Language:

english

File:

PDF, 2.86 MB

english, 2017

43

Immunoglobulin profile and Bâcell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions

Moore, Dannielle K., Leisching, Gina R., Snyders, Candice I., Gutschmidt, Andrea, Rensburg, Ilana C., Loxton, Andre G.

Journal:

Immunity, Inflammation and Disease

Year:

2020

File:

PDF, 1.09 MB

2020

44

Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy

Beltran, Caroline G. G., Heunis, Tiaan, Gallant, James, Venter, Rouxjeane, du Plessis, Nelita, Loxton, Andre G., Trost, Matthias, Winter, Jill, Malherbe, Stephanus T., Kana, Bavesh D., Walzl, Gerhard

Journal:

Frontiers in Cellular and Infection Microbiology

Year:

2020

File:

PDF, 1.23 MB

2020

45

PO 8179âMEAN LEVELS OF ENDOPLASMIC RETICULUM STRESS CHAPERONE PROTEIN â BINDING IMMUNOGLOBULIN PROTEIN (BIP) DECREASES FOLLOWING SUCCESSFUL TB TREATMENT

Motaung, Bongani, Loxton, Andre G

Journal:

BMJ Global Health

Year:

2019

File:

PDF, 62 KB

2019